Protective effect of epigallocatechin gallate against sperm abnormality in mice / 中华男科学杂志
National Journal of Andrology
; (12): 1068-1072, 2014.
Article
em Zh
| WPRIM
| ID: wpr-319566
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the protective effect of epigallocatechin gallate (EGCG) on mouse sperm in vivo.</p><p><b>METHODS</b>A total of 64 six-week-old male Kuming mice were randomly divided into eight groups of equal number to be treated with normal saline (negative control), Cyclophosphamide (CP) at 30 mg/kg (positive control), and CP followed by EGCG (experimental) at 20, 40, and 80 mg/kg, respectively, given every other day for 10 days. At 4 and 5 weeks after treatment, the bilateral testes of the mice were harvested for examination of sperm abnormality.</p><p><b>RESULTS</b>EGCG did not increase the rate of CP-induced sperm abnormality in the mice, but reduced it instead with the prolonged time of treatment.</p><p><b>CONCLUSION</b>EGCG protects mouse sperm in vivo.</p>
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Farmacologia
/
Espermatozoides
/
Fatores de Tempo
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Distribuição Aleatória
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Catequina
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Ciclofosfamida
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Toxicidade
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Mutagênicos
Limite:
Animals
Idioma:
Zh
Revista:
National Journal of Andrology
Ano de publicação:
2014
Tipo de documento:
Article