Study on preparation of salvianolic acid phospholipid compound / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 216-221, 2014.
Article
em Zh
| WPRIM
| ID: wpr-319626
Biblioteca responsável:
WPRO
ABSTRACT
To prepare salvianolic acid phospholipid compound. With the compound of salvianolic acids and soybean phospholipid as the index, mono-factor experiment and orthogonal design experiment were conducted to screen its technical parameters. According to the results, the optimal preparation conditions of salvianolic acid phospholipid compound were that THF were taken as the reaction solvent, the concentration time was 3 h, the reactant concentration was 5 g x L(-1), the mass ratio of salvianolic acids and phospholipid was 1: 1.5, and the reaction temperature was 40 degrees C. The oil/water partition coefficient of the prepared salvianolic acid phospholipid compound significant increased in water and buffers with different pH values. The results of phase analysis such as DSC, XRD and FTIR indicated that salvianolic acids existed in phospholipid in an amorphous state.
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Índice:
WPRIM
Assunto principal:
Fosfolipídeos
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Glycine max
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Temperatura
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Química
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Química Farmacêutica
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Alcenos
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Fenômenos Químicos
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Polifenóis
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Absorção Intestinal
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Metabolismo
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2014
Tipo de documento:
Article