Estimation on the HIV-1 incidence among high risk groups using the pooling RNA technique / 中华流行病学杂志
Chinese Journal of Epidemiology
; (12): 812-814, 2013.
Article
em Zh
| WPRIM
| ID: wpr-320923
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To timely identify the HIV-1 infection in window-period and to estimate the HIV-1 incidence among people who came for voluntary counseling and testing (VCT) service as well as men who have sex with men (MSM), respectively.</p><p><b>METHODS</b>HIV antibody negative samples that were determined by screening tests between January and October 2012, were collected and tested with pooling HIV-1 RNA testing technique (2-staged pooling by 50:1, 10:1). Positive cases were followed-up for HIV antibody testing while HIV incidence was calculated under Ron Brookmeyer' s method, among VCT and MSM populations.</p><p><b>RESULTS</b>Among 1400 HIV antibody negative samples of VCT, two showed HIV-1 RNA positive during the antibody window period with the HIV-1 incidence as 1.87% per year (95% CI: 1.23%-2.65% ). Among 500 HIV antibody negative samples from MSM population, two showed HIV-1 RNA positive in the antibody window period, with HIV-1 incidence as 5.31% per year (95% CI: 3.52%-7.45% ).</p><p><b>CONCLUSION</b>Pooling HIV-1 RNA testing seemed a powerful tool for HIV antibody testing in the window-period. Measures should be taken to strengthen the HIV diagnostic programs among MSM and other high risk groups,during the HIV antibody window-period. More frequent detection approach as pooling HIV-1 RNA testing might be a good choice.</p>
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Índice:
WPRIM
Assunto principal:
Sangue
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RNA Viral
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Infecções por HIV
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Programas de Rastreamento
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Epidemiologia
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Incidência
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HIV-1
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Homossexualidade Masculina
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Aconselhamento
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Genética
Tipo de estudo:
Etiology_studies
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Incidence_studies
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Prognostic_studies
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Screening_studies
Limite:
Humans
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Male
Idioma:
Zh
Revista:
Chinese Journal of Epidemiology
Ano de publicação:
2013
Tipo de documento:
Article