Association between intercellular adhesion molecule-1 K469E polymorphism and coronary heart disease in people with Uygur ethnicity, in Xinjiang / 中华流行病学杂志
Chinese Journal of Epidemiology
; (12): 1018-1022, 2013.
Article
em Zh
| WPRIM
| ID: wpr-320949
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the distribution on K469E single nucleotide polymorphism of ICAM-1 gene among people with Uygur ethnicity, in Xinjiang and to analyze the correlation between ICAM-1 gene polymorphism and coronary heart disease.</p><p><b>METHODS</b>245 patients with coronary heart disease patients and 377 healthy controls in Xinjiang Uygur population were studied. ICAM-1 gene K469E genotype located in exon 6 were detected by polymerase chain reaction-restricted fragments length polymorphism.</p><p><b>RESULTS</b>Distribution of genotypes in the two groups appeared to be in Hardy-Weinberg equilibrium (P > 0.05). The distribution of genotypes showed significant difference between the two groups (P = 0.039)and the distributions of K and E allele also presented statistically significant difference (P = 0.031). Significant difference was also observed in males(P = 0.029 for genotype, P = 0.025 for allele)but not in females. After adjusted for confounding factors, results from logistic regression analysis indicated that KK genotype was a risk factor for CHD in Uygur male population (OR = 2.389, 95% CI1.458-3.915, P = 0.001).</p><p><b>CONCLUSION</b>Genetic polymorphism of ICAM-1 K469E might increase the risk for coronary artery disease in males of Uygur patients in Xinjiang.</p>
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Índice:
WPRIM
Assunto principal:
Etnicidade
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China
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Epidemiologia
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Fatores de Risco
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Molécula 1 de Adesão Intercelular
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Doença das Coronárias
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Predisposição Genética para Doença
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Polimorfismo de Nucleotídeo Único
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Alelos
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Genética
Tipo de estudo:
Etiology_studies
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Risk_factors_studies
Limite:
Aged
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Female
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Humans
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Male
País/Região como assunto:
Asia
Idioma:
Zh
Revista:
Chinese Journal of Epidemiology
Ano de publicação:
2013
Tipo de documento:
Article