Studies on hydroxyapatite applicatied in coprecipitate of total salvianolic acids phospholipid complex / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 992-996, 2014.
Article
em Zh
| WPRIM
| ID: wpr-321380
Biblioteca responsável:
WPRO
ABSTRACT
The purpose of this research was to prepare total salvianolic acids-phytosome-HA coprecipitate to improve drug dissolution and its micromeritic properties. Firstly, the coprecipitate was prepared by solvent method and in vitro dissolution of tripterine was performed with the salvianolic acid B and danshensu as criteria. At the same time, the micromeritic properties was characterizated, the structure of samples was characterized by TEM, DSC, XRD and FTIR. Results showed that when the ratio of drug to HA was 1:2, it had a better dissolution, the accumulative drug-release percent in vitro at 60 min was over 90%. At the same time, it has good liquidity and low moisture absorption. Its micromeritic properties have improved. It is proved that the drug still existed amorphously by microstructure analysis. The preparation process is simple and feasible, it has practical value.
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Fosfolipídeos
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Precipitação Química
/
Fatores de Tempo
/
Química
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Química Farmacêutica
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Durapatita
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Alcenos
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Polifenóis
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Métodos
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2014
Tipo de documento:
Article