ROS kinase fusions are not common in Chinese patients with cholangiocarcinoma / 南方医科大学学报
Journal of Southern Medical University
; (12): 474-478, 2013.
Article
em En
| WPRIM
| ID: wpr-322019
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expressions of different forms of ROS fusions in Chinese patients with cholangiocarcinoma (CCA).</p><p><b>METHODS</b>RT-PCR was employed to examine formalin-fixed and paraffin-embedded CCA samples from stage I-IV patients for detection of ROS fusions involving Fused in Glioblastoma (FIG), solute carrier protein (SLC34A2) and major histocompatibility complex class II invariant chain (CD74). Serpin peptidase inhibitor clade A member 1 (SERPINA1) was detected as the reference gene.</p><p><b>RESULTS</b>In all the 56 CCA samples, 80.4% (45/56) were positive for SERPINA1 expression as evaluable samples. Of these evaluable samples, none expressed the ROS fusions.</p><p><b>CONCLUSION</b>ROS fusions are not common in Chinese CCA patients.</p>
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Patologia
/
Neoplasias dos Ductos Biliares
/
Proteínas Tirosina Quinases
/
Proteínas de Transporte
/
Antígenos de Diferenciação de Linfócitos B
/
Antígenos de Histocompatibilidade Classe II
/
Expressão Gênica
/
Proteínas de Fusão Oncogênica
/
Proteínas Proto-Oncogênicas
/
Inclusão em Parafina
Limite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Journal of Southern Medical University
Ano de publicação:
2013
Tipo de documento:
Article