Expressions of Raf-1 kinase, phosphorylated mitogen extracellular kinase 1, and phosphorylated extracellular signal-regulated protein kinase 1/2 in hepatocellular carcinoma and their relationship with prognosis / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
; (6): 424-428, 2010.
Article
em Zh
| WPRIM
| ID: wpr-322758
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the prognostic values of Raf-1 kinase (Raf-1), phosphorylated mitogen extracellular kinase 1 (pMEK1), and phosphorylated extracellular signal-regulated protein kinase 1/2(pERK1/2) in hepatocellular carcinoma (HCC) patients.</p><p><b>METHODS</b>We assessed the expressions of Raf-1, pMEK1, and pERK1/2 in HCC using immunohistochemical techniques. The relationships between the expressions of Raf-1, pMEK1, and pERK1/2 and the prognosis were explored.</p><p><b>RESULTS</b>The over-expression rates of Raf-1, pMEK1, and pERK1/2 in HCC were 38.3%, 46.7%, and 38.3%, respectively. The over-expressions of Raf-1, pMEK1, and pERK1/2 were positively correlated with each other (P>0.05), but had no significant correlation with sex, age, α-fetoprotein, hepatitis B surface antigen status, the TNM stage, size,differentiation and vascular invasion of tumor, and liver cirrhosis (P>0.05). Univariate survival analysis and COX proportional hazard regression model showed that Raf-1 over-expression was an independent prognostic factor of poor survival (P<0.05).</p><p><b>CONCLUSION</b>Raf-1 over-expression is an independent marker for the patients of HCC, which may provide new clue in the future targeted therapy.</p>
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1
Índice:
WPRIM
Assunto principal:
Fosforilação
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Prognóstico
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Carcinoma Hepatocelular
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Proteínas Proto-Oncogênicas c-raf
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MAP Quinase Quinase 1
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MAP Quinases Reguladas por Sinal Extracelular
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Diagnóstico
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Neoplasias Hepáticas
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Metabolismo
Tipo de estudo:
Diagnostic_studies
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Prognostic_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Acta Academiae Medicinae Sinicae
Ano de publicação:
2010
Tipo de documento:
Article