Effects of pentachlorophenol on rat sertoli cells / 中华男科学杂志
National Journal of Andrology
; (12): 261-268, 2005.
Article
em Zh
| WPRIM
| ID: wpr-323382
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To detect the toxic effects of pentachlorophenol (PCP) on cultured rat Sertoli cells.</p><p><b>METHODS</b>The viability of Sertoli cells was detected and morphological examination was performed, followed by flow cytometric assay to evaluate the toxic effect of PCP on rat Sertoli cells.</p><p><b>RESULTS</b>MTT assay showed that PCP induced a concentration- and time-dependent decrease in Sertoli cell viability. Flow cytometric assay revealed that the number of dead Sertoli cells grew along with increased exposure to PCP.</p><p><b>CONCLUSION</b>PCP, with obvious cytotoxic effects, can cause necrosis of Sertoli cells in vitro.</p>
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Pentaclorofenol
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Fisiologia
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Células de Sertoli
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Sobrevivência Celular
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Células Cultivadas
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Ratos Sprague-Dawley
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Relação Dose-Resposta a Droga
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Toxicidade
Limite:
Animals
Idioma:
Zh
Revista:
National Journal of Andrology
Ano de publicação:
2005
Tipo de documento:
Article