Plasma proteomic analysis in male normotensive, prehypertensive and hypertensive subjects / 中华心血管病杂志
Chinese Journal of Cardiology
; (12): 5-10, 2010.
Article
em Zh
| WPRIM
| ID: wpr-323888
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To compare the plasma proteome among male normotensive, prehypertensive, and hypertensive subjects.</p><p><b>METHODS</b>Plasma proteome was analyzed by two-dimensional electrophoresis combined with MALDI-TOF mass spectrometry in this case-control study among well matched male normotensive, prehypertensive and hypertensive subjects (n = 26 each).</p><p><b>RESULTS</b>The results showed that there were 22 differentially expressed protein spots among the protein samples derived from the 3 groups which corresponded to 18 proteins associated with inflammation and immunity, lipid metabolism, transport, coagulation and fibrinolysis, cell proliferation and apoptosis, and antioxidation.</p><p><b>CONCLUSION</b>Proteins were differentially expressed in male subjects with various blood pressure levels.</p>
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Pressão Sanguínea
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Estudos de Casos e Controles
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Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz
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Proteômica
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Pré-Hipertensão
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Genética
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Hipertensão
Tipo de estudo:
Observational_studies
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Risk_factors_studies
Limite:
Adult
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Humans
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Male
Idioma:
Zh
Revista:
Chinese Journal of Cardiology
Ano de publicação:
2010
Tipo de documento:
Article