Analysis on the SARS-CoV genome of PUMC01 isolate / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
; (6): 495-498, 2003.
Article
em Zh
| WPRIM
| ID: wpr-327052
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To perform variation and phylogenetics analysis on the SARS-CoV genome sequence (PUMC01) isolated in the Peking Union Medical College Hospital.</p><p><b>METHODS</b>The cDNA library of SARS-CoV (PUMC01 isolate) was constructed by means of random-priming strategy. Random selected plasmid was sequenced and the genome sequence of SARS-CoV-PUMC01 was assembled by conventional methods (The Genebank Accession No. of SARS-CoV-PUMC01 is AY350750). The variation and phylogenetics analysis were performed by comparing the PUMC01 sequence with other SARS-CoV isolates.</p><p><b>RESULTS</b>Ten variation sites were found by comparing PUMC01 isolate with Tor2 and Urbani isolates. In phylogenetic analysis of 18 SARS-CoV isolates, two classes were observed and there is different differential time between these two classes and the different isolates in each class.</p><p><b>CONCLUSIONS</b>The evidence of phylogenetic analysis of different SARS-CoV isolates from different region is instructive for understanding the clinical relations between the different isolates and the transmission chain of SARS-CoV.</p>
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Índice:
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Assunto principal:
Filogenia
/
Variação Genética
/
Proteínas Virais
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DNA Viral
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Dados de Sequência Molecular
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Sequência de Bases
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China
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Sequência de Aminoácidos
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Genoma Viral
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Análise de Sequência de DNA
País/Região como assunto:
Asia
Idioma:
Zh
Revista:
Acta Academiae Medicinae Sinicae
Ano de publicação:
2003
Tipo de documento:
Article