Single Nucleotide Polymorphisms of Paclitaxel-induced Peripheral Sensory Neuropathy in Chinese Han Population / 中国医学科学院学报

ABSTRACT

Objective To study the single nucleotide polymorphisms (SNPs)that predict a patient's risk of grade 2-3 paclitaxel-induced peripheral sensory neuropathy (PSN) in Chinese Han populations.Methods Totally 216 patients received paclitaxel in Peking Union Medical College Hospital from May 2014 to December 2016 were enrolled.DNA was isolated from peripheral blood.Genotyping for eight candidate SNPs was performed on Sequenom-MassARRARYiPLEX platform.Patients were followed up and PSN was assessed by trained physicians according to National Cancer Institute-Common Terminology Criteria for Adverse Events v4.03.Results A total of 209 patients entered the final analysis.Among the candidate SNPs,only rs4141404A>C(LIMK2) was significantly associated with grade 2/3 PSN (OR4.32,95%CI2.37-7.89,P<0.0001).In multivariate logistic regression analysis,both rs4141404A>C(LIMK2) and history of receiving platinum compound (OR2.70,95%CI1.32-5.51,P=0.007) were associated with grade 2/3 PSN.Conclusion rs4141404A>C(LIMK2) may be the markers of risk of grade 2/3 PSN.