Resveratrol enhances radiosensitivity of human hypopharyngeal carcinoma cell line in nude mice / 南方医科大学学报

ABSTRACT

<p><b>OBJECTIVE</b>To study the radiosensitizing effect of resveratrol on human hypo pharyngeal squamous cell carcinoma (FaDu) cells in nude mice.</p><p><b>METHODS</b>Forty-three nude mice bearing FaDu cell xenografts were randomized into control group, radiotherapy (12 Gy) group, resveratrol treatment (50 mg/kg) group, and radiotherapy plus resveratrol treatment group. After corresponding treatments, the tumor volume in the mice was measured every 3 days, and the microvessel density (MVD) in the tumor was evaluated with CD31 immunofluorescence histochemical staining.</p><p><b>RESULTS</b>The tumor volume and weight were the smallest in mice receiving radiotherapy plus resveratrol treatment (P<0.05) but comparable between those having resveratrol treatment alone and the control mice. Radiotherapy plus resveratrol treatment resulted in a tumor inhibition rate of 76.64% and a significantly decreased MVD in the tumor compared with the other 3 groups.</p><p><b>CONCLUSION</b>Resveratrol can produce a radiosensitizing effect on human hypopharyngeal carcinoma in nude mice.</p>