Transmission disequilibrium test of polymorphisms of serotonin transporter gene and schizophrenia based on family trios / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 342-344, 2003.
Article
em Zh
| WPRIM
| ID: wpr-329466
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship between two polymorphisms (Intronic VNTR and 5-HTTLPR) of the serotonin transporter gene and schizophrenia.</p><p><b>METHODS</b>A set of 314 schizophrenic trio samples collected from Shanghai, Xi'an and Jilin regions of China independently was subjected to analysis of the polymorphisms by transmission/disequilibrium test(TDT).</p><p><b>RESULTS</b>No significantly preferential transmission of any allele was detected from both polymorphisms investigated.</p><p><b>CONCLUSION</b>The results suggest that the serotonin transporter gene is unlikely to have a major contribution to susceptibility to schizophrenia in Han Chinese population.</p>
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Índice:
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Assunto principal:
Polimorfismo Genético
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Esquizofrenia
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Núcleo Familiar
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Reação em Cadeia da Polimerase
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Repetições Minissatélites
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Predisposição Genética para Doença
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Proteínas da Membrana Plasmática de Transporte de Serotonina
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Genética
Limite:
Adult
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2003
Tipo de documento:
Article