Effect of chronic transauricular kindled seizures on passive-avoidance test memory retention in rats / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
; (6): 419-423, 2006.
Article
em Zh
| WPRIM
| ID: wpr-332132
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WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate effect of chronic transauricular kindled seizures on passive-avoidance test memory retention in rats.</p><p><b>METHODS</b>Chronic transauricular kindled seizures was induced by repeated application of initially subconvulsive electrical stimulation through ear-clip electrodes once every 24 h until the occurrence of 3 consecutive clonic-tonic seizures. A passive avoidance test was used to measure memory retention ability. Morphological changes in neurons of hippocampal CA1 region was examined after HE staining. Histamine, gamma-aminobutyric acid (GABA) and glutamate levels in the hippocampus were measured by high performance liquid chromatography (HPLC).</p><p><b>RESULT</b>Chronic transauricular kindled seizures impaired passive-avoidance test memory retention in rats. The damaged CA1 neurons were observed and histamine content in the hippocampus markedly decreased 24 h after the end of kindling in the chronic transauricular kindled rats.</p><p><b>CONCLUSION</b>Chronic transauricular kindled seizure impaired passive-avoidance test memory retention, and it might be due to the damaged CA1 neurons and a decrease of histamine in the hippocampus induced by epilepsy.</p>
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Assunto principal:
Patologia
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Convulsões
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Aprendizagem da Esquiva
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Histamina
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Ratos Sprague-Dawley
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Ácido gama-Aminobutírico
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Hipocampo
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Excitação Neurológica
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Transtornos da Memória
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Metabolismo
Limite:
Animals
Idioma:
Zh
Revista:
Journal of Zhejiang University. Medical sciences
Ano de publicação:
2006
Tipo de documento:
Article