Effects of paclitaxel loaded ultrasound contrast agents on cell cycles and ultrastructural features of HepG2 cells / 中华肝脏病杂志
Chinese Journal of Hepatology
; (12): 360-362, 2008.
Article
em Zh
| WPRIM
| ID: wpr-332234
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVES</b>To investigate the effects of paclitaxel loaded ultrasound contrast agents on cell cycles and ultrastructural features of HepG2 cells.</p><p><b>METHODS</b>HepG2 cells were cultured, and divided into a blank control group, a paclitaxel group, an ultrasound contrast agents group, and a paclitaxel loaded ultrasound contrast agents group. Cell cycles of the four groups were detected by flow cytometry, and the ultrastructural changes of the cells were observed under a transmission electron microscope.</p><p><b>RESULTS</b>Paclitaxel loaded ultrasound contrast agents blocked the HepG2 cells at their G2/M phases, and it also induced more apoptosis of the HepG2 cells.</p><p><b>CONCLUSIONS</b>Paclitaxel loaded ultrasound contrast agents can block HepG2 cells at the G2/M phase and induce apoptosis of the cells.</p>
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Farmacologia
/
Ciclo Celular
/
Paclitaxel
/
Apoptose
/
Meios de Contraste
/
Microscopia Eletrônica de Transmissão
/
Células Hep G2
Limite:
Humans
Idioma:
Zh
Revista:
Chinese Journal of Hepatology
Ano de publicação:
2008
Tipo de documento:
Article