Effects of SUMOylation on the subcellular localization and function of DAXX / 生理学报
Acta Physiologica Sinica
; (6): 89-95, 2013.
Article
em Zh
| WPRIM
| ID: wpr-333130
Biblioteca responsável:
WPRO
ABSTRACT
Death domain-associated protein (DAXX) as a multifunctional nuclear protein widely resides in nucleolus, nucleoplasm, chromatin, promyelocytic leukaemia nuclear bodies (PML-NBs) and cytoplasm. It plays significant roles in transcriptional regulation, apoptosis, cell cycle and other biological activities. Small ubiquitin-like modifier (SUMO) is required for SUMOylation which is a highly conserved post-translational modification in a wide variety of cellular processes. Numerous studies demonstrated that SUMOylation has a great effect on the subcellular localization and functional regulation of DAXX. This review will provide a summary for SUMOylation of DAXX.
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Fisiologia
/
Proteínas Nucleares
/
Regulação da Expressão Gênica
/
Proteínas Adaptadoras de Transdução de Sinal
/
Sumoilação
Limite:
Humans
Idioma:
Zh
Revista:
Acta Physiologica Sinica
Ano de publicação:
2013
Tipo de documento:
Article