Different firing patterns induced by veratridine and aconitine in injured dorsal root ganglion neurons / 生理学报
Acta Physiologica Sinica
; (6): 169-174, 2005.
Article
em En
| WPRIM
| ID: wpr-334176
Biblioteca responsável:
WPRO
ABSTRACT
Ectopic spontaneous activity originated from the injured dorsal root ganglion (DRG) neurons in rats was recorded through single dorsal root fiber. The firing patterns induced by veratridine and aconitine, inhibitors of inactivation gate of sodium channel operating on different binding sites, were compared. In the same neuron, veratridine (1.5 approximately 5.0 micromol/L) caused slow wave oscillations of interspike intervals (ISIs), while aconitine (10 approximately 200 micromol/L) caused tonic firing. Moreover, even if the background firing patterns were various and the reagent concentrations used were different, veratridine and aconitine still induced slow wave oscillations and tonic firing patterns, respectively. The results suggest that veratridine and aconitine induce different firing patterns in injured DRG neurons, which may relate to their inhibitory effects on different binding sites of the sodium channel.
Texto completo:
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Índice:
WPRIM
Assunto principal:
Patologia
/
Farmacologia
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Fisiologia
/
Veratridina
/
Ferimentos e Lesões
/
Aconitina
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Canais de Sódio
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Ratos Sprague-Dawley
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Fenômenos Eletrofisiológicos
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Agonistas de Canais de Sódio
Limite:
Animals
Idioma:
En
Revista:
Acta Physiologica Sinica
Ano de publicação:
2005
Tipo de documento:
Article