Surveillance for occult HBV infection and HBsAg variants in blood donors / 病毒学报
Chinese Journal of Virology
; (6): 178-184, 2009.
Article
em Zh
| WPRIM
| ID: wpr-334754
Biblioteca responsável:
WPRO
ABSTRACT
Occult hepatitis B virus (HBV) infection status of blood donors in a southern city in China was investigated by immunological assays and nucleic acid testing. Overall, 17 (0.19%, 95% CI 0.11%-0.30%) of the 9023 HBsAg negative samples were found to be positive for the presence of HBV DNA. "A" epitope sequences were obtained from 14 among them. Mutation(s) in aa124-aa147 existed in 6 (42.9%, 6/14) samples and 4 (66.7%, 4/6)were G145R mutation. Ratio of genotype C in occult donors (10/17) was statistically higher than HBs-positive donors (0/15, P<0.01), which implied that HBV genotype C leaded to occult infection more easily.
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Índice:
WPRIM
Assunto principal:
Fisiologia
/
Virologia
/
Doadores de Sangue
/
Testes Imunológicos
/
DNA Viral
/
China
/
Vírus da Hepatite B
/
Epidemiologia
/
Alinhamento de Sequência
/
Classificação
Tipo de estudo:
Diagnostic_studies
/
Screening_studies
Limite:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
País/Região como assunto:
Asia
Idioma:
Zh
Revista:
Chinese Journal of Virology
Ano de publicação:
2009
Tipo de documento:
Article