Circular RNA in human disease and their potential clinic significance / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 133-137, 2017.
Article
em Zh
| WPRIM
| ID: wpr-335166
Biblioteca responsável:
WPRO
ABSTRACT
Circular RNAs (circ RNAs) are a novel type of RNA that, unlike linear RNAs, form a covalently closed continuous loop and are highly represented in the eukaryotic transcriptome. They share a stable structure, high expression and often exhibit tissue/developmental-stage-specific expression. Emerging evidence indicates that circRNAs might play important roles in human disease, such as cancer, neurological disorders and atherosclerotic vascular disease risk. The huge potentials of circRNAs are recently being discovered from the laboratory to the clinic. CircRNAs might be developed as a potential novel and stable biomarker and potential drugs used in disease diagnosis and treatment. Here, we review the current understanding of the roles of circRNAs in human disease and their potential clinic significance in disease.
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Terapêutica
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RNA
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Biomarcadores
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Transdução de Sinais
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Regulação da Expressão Gênica
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Doença
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Estabilidade de RNA
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Diagnóstico
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Genética
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Neoplasias
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
Zh
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2017
Tipo de documento:
Article