Isolation, identification and structural characterization of secondary metabolites from amarine sponge-derived rare actinobacterium Dermacoccus sp. X4 / 生物工程学报
Chinese Journal of Biotechnology
; (12): 599-609, 2016.
Article
em Zh
| WPRIM
| ID: wpr-337438
Biblioteca responsável:
WPRO
ABSTRACT
We isolated and identified the symbiotic and adnascent microorganisms from an unidentified sponge collected from 10-meter-deep seawater of the Paracel Islands in China. A total of 16 strains were obtained and identified. Through bacteriostatic activity assay, one of the strains, Dermacoccus sp. X4, was found to effectively inhibit the growth of Staphylococcus aureus. Subsequently, its secondary metabolites were purified by silica gel partition, octadecylsilane (ODS) reverse phase, Sephadex™LH-20 size exclusion, and C18 reverse phase chromatography. Using liquid chromatography, mass spectrometry, and nuclear magnetic resonance, three of the purified compounds were structurally characterized to be one 3-(4-hydroxybenzyl) hexahydropyrrolo [1,2-a]pyrazine-1,4-dione and two indole acid glycerides. This is the first report about indole acid glyceride isolated from microbial secondary metabolites, enriching marine drug candidate resources.
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Texto completo:
1
Índice:
WPRIM
Assunto principal:
Farmacologia
/
Poríferos
/
Água do Mar
/
Espectrometria de Massas
/
Staphylococcus aureus
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Actinomycetales
/
Espectroscopia de Ressonância Magnética
/
Química
/
China
/
Cromatografia Líquida
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
País/Região como assunto:
Asia
Idioma:
Zh
Revista:
Chinese Journal of Biotechnology
Ano de publicação:
2016
Tipo de documento:
Article