Establishment of rat model of ischemic stroke with qi deficiency and blood stasis syndrome and its evaluation system / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
; (12): 343-346, 2009.
Article
em Zh
| WPRIM
| ID: wpr-337508
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To probe into the establishing method and the evaluating system for rat model of ischemic stroke with qi deficiency and blood stasis syndrome (QDBS).</p><p><b>METHODS</b>A rat model of ischemic stroke of QDBS was established by continual exhaustive swimming followed with middle cerebral artery occlusion (MCAO), and evaluated by analyzing the changes of exterior signs, tongue figure, hemorrheologic characters and brain histomorphology in the model rats.</p><p><b>RESULTS</b>The model rats showed a state of QDBS in the course of continual exhaustive swimming, such as slower weight gain, postponed food intake, darker tongue and longer sublingual veins; and presented the characteristics of cerebral ischemia with QDBS syndrome after MCAO, they were inactive, weak, and hemiplegic, with dark purple tongue and longer blue sublingual veins. Moreover, hemorrheologic examinations showed blood hyperviscosity and high platelet aggregation rate, and histomorphologic examinations showed a special figure of ischemic changes.</p><p><b>CONCLUSION</b>Continual exhausting swimming followed by MCAO is a method for establishing a rat model of ischemic stroke with QDBS syndrome, and its evaluating system could be constituted by multiple criteria, including exterior signs, tongue figure, hemorrheologic and histomorphologic indexes, etc.</p>
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Índice:
WPRIM
Assunto principal:
Isquemia Encefálica
/
Deficiência da Energia Yang
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Ratos Sprague-Dawley
/
Qi
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Acidente Vascular Cerebral
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Diagnóstico Diferencial
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Modelos Animais de Doenças
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Medicina Tradicional Chinesa
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Animals
Idioma:
Zh
Revista:
Chinese Journal of Integrated Traditional and Western Medicine
Ano de publicação:
2009
Tipo de documento:
Article