Effect of xiaoyu zhixue tablet on expression of thrombin receptor glycoproteins Eb/IX/V and glycoprotein Ibalpha in patients with hemorrhagic thrombopathy / 中国中西医结合杂志

ABSTRACT

<p><b>OBJECTIVE</b>To observe the effect of Xiaoyu Zhixue Tablet (XYZXT) on expression of platelet membrane glycoproteins (GP) Ib/IX/V complex and its component GP Ibalpha in patients with hemorrhagic thrombopathy, so as to explore its possible mechanism.</p><p><b>METHODS</b>Ninety-eight patients with hemorrhagic thrombopathy were randomly assigned to two groups, the TCM group (68 cases) treated with XYZXT and the Western medicine group (30 cases) treated with adrenosin, vitamins C, K and P, for 6 months totally. The hemostatic effect and the platelet aggregation recovery rate in the two groups were observed. And expressions of GPIb/IX/V complex and GP Ibalpha were analyzed by flow cytometry in both groups before and after treatment as well as in 34 healthy persons for control.</p><p><b>RESULTS</b>The hemostatic effective rate was 89.7% in the TCM group and 46.7% in the Western medicine group (u= 5.68, P < 0.01); the platelet aggregation recovery rate in the two groups was 67.6% and 3.3% respectively (chi2 = 34. 49, P < 0.01). The fluorescence intensity of GPIb/IX/V complex and GPIbalpha were lower in both groups before treatment than those of the healthy control (P < 0.05), but after treatment the two markers elevated in the TCM group, approaching the control (P > 0.05), and significantly higher than those in the Western medicine group (P < 0.05).</p><p><b>CONCLUSION</b>The partial mechanism of XYZXT in treating hemorrhagic thrombopathy might be its regulation on the expression of thrombin receptor at the receptor protein level.</p>