Impact of neoadjuvant radiochemotherapy on erectile and urinary functions in mid-low rectal cancer patients: A prospective non-randomized controlled trial / 中华胃肠外科杂志
Chinese Journal of Gastrointestinal Surgery
; (12): 45-49, 2016.
Article
em Zh
| WPRIM
| ID: wpr-341579
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the impact of neoadjuvant radiochemotherapy on erectile and urinary functions in mid-low rectal cancer patients.</p><p><b>METHODS</b>Seventy mid-low rectal cancer patients from January 2012 to May 2013 in The Sixth Affiliated Hospital, Sun Yat-sen University were prospectively enrolled. According to tumor staging and patient decision, patients received neoadjuvant radiochemotherapy(50 Grays administered over a six-week period and four cycles of concomitant mFOLFOX6 chemotherapy followed by operation (study group) or surgery alone(control group). Dropouts, loss to follow up and relapse during follow-up were removed from the analysis. A total of 30 patients stayed in study group and 29 patients in control group. To assess erectile and urination functions, the five-item version of the international index of erectile function (IIEF-5) and the international prostate symptom score (IPSS) questionnaires were used before therapy and 12 months after surgery.</p><p><b>RESULTS</b>In both study and control groups, total IIEF-5 score was decreased significantly at postoperative 12-month compared to initial assessment(P<0.01). Compared with control group, IIEF-5 score change was significantly higher in study group (9.6 ± 6.1 vs. 5.3 ± 5.3; P<0.01). Total IPSS score in both groups was increased significantly at postoperative 12-month compared to initial assessment(P<0.05). No significant difference was found in IPSS score change between the two groups (3.0 ± 3.4 vs. 1.5 ± 3.0, P>0.05). Univariate analysis on study group showed that age, tumor location and maximal diameter were associated with erectile dysfunction. Age was associated with urination dysfunction (all P<0.05).</p><p><b>CONCLUSION</b>Neoadjuvant radiochemotherapy has significant impact on erectile dysfunction after surgery in mid-low rectal cancer patients.</p>
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Índice:
WPRIM
Assunto principal:
Neoplasias Retais
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Incontinência Urinária
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Estudos Prospectivos
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Inquéritos e Questionários
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Terapia Neoadjuvante
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Quimiorradioterapia
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Disfunção Erétil
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Estadiamento de Neoplasias
Tipo de estudo:
Clinical_trials
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Observational_studies
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Prognostic_studies
Limite:
Humans
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Male
Idioma:
Zh
Revista:
Chinese Journal of Gastrointestinal Surgery
Ano de publicação:
2016
Tipo de documento:
Article