Mechanisms of increased survival rate by administration of AG490 in rats following extensive liver resection / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
; (6): 73-76, 2005.
Article
em Zh
| WPRIM
| ID: wpr-343764
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the mechanism by which AG490 improves the survival rate of rats following extensive liver resection.</p><p><b>METHODS</b>Thirty-eight rats were randomly divided into two groups after surgery: control group (n=10), without treatment; (2) AG490 group (n=28), with AG490 (1 mg x kg(-1) x 12 h(-1)) administrated intraperitoneally immediately and 36 hours after the operation. The survival rate was observed and the serum liver functions were measured.</p><p><b>RESULTS</b>The survival rates of control group and AG490 group were 0% and 25%. AG490 group had significantly better blood glucose and aminotransferase levels (P < 0.05) than control group; serum bilirubin levels significantly decreased 48 hours after the operation. Serum protein levels in both two groups had slow decrease but without statistical significance (P > 0.05).</p><p><b>CONCLUSIONS</b>AG490 can significantly increase the survival rate of rats following extensive liver resection. Such a benefit mainly results from the protection towards residual liver function rather than from the promotion of liver regeneration.</p>
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Índice:
WPRIM
Assunto principal:
Farmacologia
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Aspartato Aminotransferases
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Bilirrubina
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Sangue
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Glicemia
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Proteínas Tirosina Quinases
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Distribuição Aleatória
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Taxa de Sobrevida
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Ratos Sprague-Dawley
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Tirfostinas
Limite:
Animals
Idioma:
Zh
Revista:
Acta Academiae Medicinae Sinicae
Ano de publicação:
2005
Tipo de documento:
Article