LEDGF/p75: a novel target for anti-HIV therapy and advances in the study of its related inhibitors / 药学学报
Acta Pharmaceutica Sinica
; (12): 953-960, 2009.
Article
em Zh
| WPRIM
| ID: wpr-344013
Biblioteca responsável:
WPRO
ABSTRACT
LEDGF/p75 is a newly found cell cofactor, which plays an essential role in the integration of HIV-1 cDNA into host chromosomes. LEDGF/p75 tethers HIV integrase to chromatin, protects it from degradation, and strongly influences the genome-wide pattern of HIV integration. Depleting the protein from cells or over-expressing the integrase-binding domain of LEDGF/p75 blocks viral replication. The essential role of LEDGF/p75 in HIV-1 replication makes it a new target for anti-HIV-1 drug development. This article reviews the function of LEDGF/p75, LEDGF/p75-integrase interaction and LEDGF/p75 inhibitors.
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Farmacologia
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Fisiologia
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Ligação Proteica
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Química
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HIV-1
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Integrase de HIV
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Fármacos Anti-HIV
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Peptídeos e Proteínas de Sinalização Intercelular
/
Metabolismo
Idioma:
Zh
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2009
Tipo de documento:
Article