Preparation of the oral self-microemulsifying drug delivery system of GBE50 / 药学学报
Acta Pharmaceutica Sinica
; (12): 803-808, 2009.
Article
em Zh
| WPRIM
| ID: wpr-344102
Biblioteca responsável:
WPRO
ABSTRACT
To prepare the oral self-microemulsifying drug delivery system (SMEDDS) of GBE50, balance solubility method was used to screen emulsifier and assistant emulsifier; a pseudo-tamary phase diagram was used to prepare microemulsion; and orthogonal design was used to optimize formulation. Self-microemulsifying efficiency, dissolution, stability and pharmacokinetics of the preparation were studied. As a result, GBE50-SMEDDS of IPM, Cremophor EL, 1,2-propanediol and GBE50 could be self emulsified to form stable microemulsion with particle diameter between 20 and 50 nm when emulsifying with water. Its self-microemulsifying efficiency and dissolution are quick with good stability and it has a higher bioavailability than market existing agents Xingling particles. GBE50-SMEDDS is stable and effective.
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Índice:
WPRIM
Assunto principal:
Medicamentos de Ervas Chinesas
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Farmacocinética
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Disponibilidade Biológica
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Tecnologia Farmacêutica
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Sistemas de Liberação de Medicamentos
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Ginkgolídeos
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Métodos
Idioma:
Zh
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2009
Tipo de documento:
Article