Association of Hair Manganese Level with Symptoms in Attention-Deficit/Hyperactivity Disorder
Psychiatry Investigation
; : 66-72, 2015.
Article
em En
| WPRIM
| ID: wpr-34476
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE:
The study examined the association between hair manganese level and symptoms of attention-deficit/hyperactivity disorder (ADHD) in Korean children.METHODS:
Forty clinic-referred children with ADHD and 43 normal control children participated in this study. The participants were 6-15 years old and were mainly from the urban area of Seoul, Korea. ADHD was diagnosed using the Diagnostic and Statistical Manual of Mental Disorders, 4th edition and Kiddie-Schedule for Affective Disorders and Schizophrenia-Present and Lifetime Version-Korean Version. The severity and symptoms of ADHD was evaluated according to the ADHD Diagnostic System, and parent's Korean ADHD Rating Scale (K-ARS). All participants completed intelligence test and hair mineral analysis. We divided the data of hair Mn into two groups to determine whether a deficit or excess of Mn are associated with ADHD. Multiple logistic regression analyses were performed to identify hair manganese levels associated with ADHD, controlling for age, sex, and full scale intelligence quotient (IQ).RESULTS:
The proportion of abnormal range Mn group was significantly high in ADHD compared to controls. However, after statistical control for covariates including age and sex, abnormal range Mn group was significantly associated with ADHD (OR=6.40, 95% CI=1.39-29.41, p=0.017).CONCLUSION:
The result of this study suggests that excess exposure or deficiency of Mn were associated with ADHD among children in Korea. Further investigation is needed to evaluate the effects of hair manganese levels on symptoms in ADHD.Palavras-chave
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Índice:
WPRIM
Assunto principal:
Modelos Logísticos
/
Transtornos do Humor
/
Manual Diagnóstico e Estatístico de Transtornos Mentais
/
Seul
/
Cabelo
/
Inteligência
/
Testes de Inteligência
/
Coreia (Geográfico)
/
Manganês
Tipo de estudo:
Diagnostic_studies
/
Guideline
/
Risk_factors_studies
Limite:
Child
/
Humans
País/Região como assunto:
Asia
Idioma:
En
Revista:
Psychiatry Investigation
Ano de publicação:
2015
Tipo de documento:
Article