Lectin-like oxidized low-density lipoprotein receptor-1: protein, ligands, expression and pathophysiological significance / 中华医学杂志(英文版)
Chinese Medical Journal
; (24): 421-426, 2007.
Article
em En
| WPRIM
| ID: wpr-344880
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To review the recent research progress in lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) including its protein, ligands, expression and pathophysiological significance. Data sources Information included in this article was identified by searching of PUBMED (1997 - 2006) online resources using the key term LOX-1.</p><p><b>STUDY SELECTION</b>Mainly original milestone articles and critical reviews written by major pioneer investigators of the field were selected.</p><p><b>RESULTS</b>The key issues related to the LOX-1 protein as well as ligands for LOX-1. Factors regulating the expression of LOX-1 were summarized. The pathophysiological functions of LOX-1 in several diseases were discussed.</p><p><b>CONCLUSIONS</b>Identification of LOX-1 and a definition of its biological role in pathophysiologic states provide deeper insight into the pathogenesis of some cardiovascular diseases especially in atherosclerosis and provide a potential selective therapeutic approach. LOX-1 is unlocking and drugs targeting LOX-1 might be a promising direction to explore.</p>
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Osteoartrite
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Fisiologia
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Artrite Reumatoide
/
Química
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Aterosclerose
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Receptores Depuradores Classe E
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Genética
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Ligantes
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Infarto do Miocárdio
Tipo de estudo:
Prognostic_studies
Limite:
Animals
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Humans
Idioma:
En
Revista:
Chinese Medical Journal
Ano de publicação:
2007
Tipo de documento:
Article