Association between vitamin D receptor gene polymorphisms and pediatric Crohn's disease in China: a study based on gene sequencing / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 1006-1008, 2013.
Article
em Zh
| WPRIM
| ID: wpr-345660
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association between TaqI, BsmI, and ApaI polymorphisms of vitamin D receptor (VDR) gene and pediatric Crohn's disease (CD) in China.</p><p><b>METHODS</b>Nineteen children with CD were selected as a case group, and 122 healthy children who underwent physical examination were selected as a control group. Serum 25-hydroxyvitamin D3 [25(OH)D3] levels were measured using ELISA. The TaqI, BsmI, and ApaI polymorphisms of VDR gene were determined by gene sequencing, and the two groups were compared in terms of genotype and allele frequencies.</p><p><b>RESULTS</b>The case group had significantly lower serum 25(OH)D3 levels than the control group (17.3±2.4 ng/mL vs 26.9±2.1 ng/mL; P<0.05). There were no significant differences in the frequencies of genotypes and alleles of TaqI, BsmI, and ApaI polymorphisms between the case and control groups (P>0.05).</p><p><b>CONCLUSIONS</b>Children with CD have low serum 25(OH)D3 levels. TaqI, BsmI, and ApaI polymorphisms of VDR gene may not be associated with susceptibility to CD among the Chinese population.</p>
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Índice:
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Assunto principal:
Sangue
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Calcifediol
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Doença de Crohn
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Análise de Sequência de DNA
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Receptores de Calcitriol
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Polimorfismo de Nucleotídeo Único
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Genética
Limite:
Adolescent
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Child
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Child, preschool
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Chinese Journal of Contemporary Pediatrics
Ano de publicação:
2013
Tipo de documento:
Article