Recent progress of mitochondrial quality control in ischemic heart disease and its role in cardio-protection of vagal nerve / 生理学报
Acta Physiologica Sinica
; (6): 579-586, 2017.
Article
em Zh
| WPRIM
| ID: wpr-348240
Biblioteca responsável:
WPRO
ABSTRACT
Ischemic heart disease (IHD) is the life-threatening cardiovascular disease. Mitochondria have emerged as key participants and regulators of cellular energy demands and signal transduction. Mitochondrial quality is controlled by a number of coordinated mechanisms including mitochondrial fission, fusion and mitophagy, which plays an important role in maintaining healthy mitochondria and cardiac function. Recently, dysfunction of each process in mitochondrial quality control has been observed in the ischemic hearts. This review describes the mechanism of mitochondrial dynamics and mitophagy as well as its performance linked to myocardial ischemia. Moreover, in combination with our study, we will discuss the effect of vagal nerve on mitochondria in cardio-protection.
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WPRIM
Idioma:
Zh
Revista:
Acta Physiologica Sinica
Ano de publicação:
2017
Tipo de documento:
Article