The transporters of intestinal tract and their study methods / 药学学报
Acta Pharmaceutica Sinica
; (12): 370-376, 2011.
Article
em Zh
| WPRIM
| ID: wpr-348946
Biblioteca responsável:
WPRO
ABSTRACT
The absorption of oral drug in the intestine is an important factor to determine the drug bioavailability. There are many intestinal transporters mediating drug absorption, distribution, excretion and drug-drug interaction. Understanding the transport mechanism can improve the effectiveness and safety of drug and guide clinical rational use of drugs. The in vivo and in vitro methods are used to predict the transport mechanism of drugs by intestinal transporters in the intestine. The purposes of this article are to introduce the main transporters in the intestinal tract, to explain the transport mechanism and to summarize the advantages and disadvantages of the research methods of them.
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Proteínas de Membrana Transportadoras
/
Disponibilidade Biológica
/
Transportadores de Cassetes de Ligação de ATP
/
Proteínas de Transporte de Ânions
/
Simportadores
/
Transportador 1 de Peptídeos
/
Absorção Intestinal
/
Metabolismo
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
Zh
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2011
Tipo de documento:
Article