Existing problems and strategies in liposome-mediated nucleic acid delivery / 药学学报
Acta Pharmaceutica Sinica
; (12): 261-268, 2011.
Article
em Zh
| WPRIM
| ID: wpr-348967
Biblioteca responsável:
WPRO
ABSTRACT
Liposome-mediated nucleic acid delivery has been a focus recently, but in the course of delivering nucleic acid, some hurdles seriously limit the nucleic acid exerting treatment effect. This review refers to a series of problems such as low blood stability, reticuloendothelial system absorption, the lower targeting of liposome and the restriction of endosomal escape which are suffered in liposome-mediated nucleic acid delivery; and gives a detail introduction of strategies such as PEGylation, ligand modification, photochemical internalization, the application of degradation liposome and membrane-lytic peptide, to overcome those problems.
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Polietilenoglicóis
/
Polímeros
/
Sistema Fagocitário Mononuclear
/
Farmacocinética
/
Ácidos Nucleicos
/
Química
/
Nanopartículas
/
Processos Fotoquímicos
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Lipossomos
/
Metabolismo
Limite:
Animals
/
Humans
Idioma:
Zh
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2011
Tipo de documento:
Article