Research progress of the biological characteristics of IkappaB kinase and its inhibitors / 药学学报
Acta Pharmaceutica Sinica
; (12): 253-260, 2011.
Article
em Zh
| WPRIM
| ID: wpr-348968
Biblioteca responsável:
WPRO
ABSTRACT
The NF-kappaB pathway regulates the expression of over 150 target genes, e.g., cytokines, chemokines, leukocyte adhesion molecules and inducible effector enzymes. Consequently, it plays a crucial role in innate and adaptive immune responses, inflammatory response, stress responses, apoptosis and so on. IkappaB kinase (IKK) is the key of this pathway, and it owns a special structure which consists of catalytic subunit and regulatory subunit. Naturally, the activation of IKK needs the interaction of the two subunits and phosphorylation by its upstream kinases. Actually, there are two methods of activation of the NF-kappaB pathway, and both of the methods need the IKK complex. Given to the crucial role of IKK, researchers have isolated and synthesized amounts of IKK inhibitors, and these provide a great convenience to develop novel anti-inflammatory and anti-tumor drugs.
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Farmacologia
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Fosforilação
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Fisiologia
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Transdução de Sinais
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Química
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NF-kappa B
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Ativação Enzimática
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Inibidores Enzimáticos
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Quinase I-kappa B
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Metabolismo
Limite:
Animals
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Humans
Idioma:
Zh
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2011
Tipo de documento:
Article