MicroRNAs in nasopharyngeal carcinoma / 癌症
Chinese Journal of Cancer
; (12): 539-544, 2014.
Article
em En
| WPRIM
| ID: wpr-349629
Biblioteca responsável:
WPRO
ABSTRACT
MicroRNAs (miRNAs) provide insight into both the biology and clinical behavior of many human cancers, including nasopharyngeal carcinoma (NPC). The dysregulation of miRNAs in NPC results in a variety of tumor-promoting effects. Furthermore, several miRNAs are prognostic markers for NPC. In addition to cellular miRNAs, NPC samples also often contain miRNAs encoded by Epstein-Barr virus, and these miRNAs may impact NPC biology by targeting both cellular and viral genes. Given their numerous putative roles in NPC development and progression, a thorough understanding of the impact of miRNA dysregulation in NPC is expected to shed light on useful biomarkers and therapeutic targets for the clinical management of this disease. In this review, we describe the efforts to date to identify and characterize such miRNAs in the context of NPC.
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Carcinoma
/
Transformação Celular Neoplásica
/
Neoplasias Nasofaríngeas
/
Herpesvirus Humano 4
/
MicroRNAs
Limite:
Humans
Idioma:
En
Revista:
Chinese Journal of Cancer
Ano de publicação:
2014
Tipo de documento:
Article