The protective of Shenfu injections on hemodynamics and myocardial enzyme after myocardial ischemia/reperfusion injury / 中国应用生理学杂志
Chinese Journal of Applied Physiology
; (6): 155-157, 2011.
Article
em Zh
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| ID: wpr-351213
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ABSTRACT
<p><b>OBJECTIVE</b>To study the protective effect of Shenfu (Chinese traditional medicine) injections on myocardial ischemia/reperfusion (I/R) injury in rabbits.</p><p><b>METHODS</b>Thirty rabbits were divided into three groups (n = 10) randomly: control group, myocardial ischemia/ reperfusion group (MI/RI) and Shenfu injections extract group, three groups of rabbits were fed respectively with standard diet. After giving medicine 10 minutes, the myocardial ischemia/reperfusion injury animal model was established by ligaturing rabbits left ventricutar branch of coronary artery, and observing the changes of enzyme/hemodynamics during myocardial ischemia/reperfusion.</p><p><b>RESULTS</b>In model group myocardial function of shrink went down, the amount of malondialdehyde (MDA) was higher, the activity of superoxide dismutase (SOD), glutathine peroxidease (GSH-Px), Na(+) -K(+) -ATP and Ca(2+) -ATP were lower, lactic dehydrogenase (LDH) and creatine kinase(CK) were released compared with those in model group. Shenfu injections could recover left ventricular systolic pressure (LVSP) and +/- dp/dt(max), decrease left ventricular end-diastolic pressure(LVEDP), inhibit the increasing of MDA, LDH and CK, and increase the activaty of SOD, GSH-PX, Na(+) -K(+) -ATP and Ca(2+) -ATP.</p><p><b>CONCLUSION</b>Shenfu injections can obviously protect myocardial ischemia/reperfusion injury.</p>
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Índice:
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Assunto principal:
Farmacologia
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Superóxido Dismutase
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Medicamentos de Ervas Chinesas
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Traumatismo por Reperfusão Miocárdica
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Distribuição Aleatória
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Isquemia Miocárdica
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ATPases Transportadoras de Cálcio
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ATPase Trocadora de Sódio-Potássio
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Glutationa Peroxidase
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Hemodinâmica
Limite:
Animals
Idioma:
Zh
Revista:
Chinese Journal of Applied Physiology
Ano de publicação:
2011
Tipo de documento:
Article