Molecular mechanism of the sensitivity of myocardial cell injury after severe hypoxia / 中华烧伤杂志
Chinese Journal of Burns
; (6): 134-136, 2003.
Article
em Zh
| WPRIM
| ID: wpr-352303
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the molecular mechanism of the sensitivity of myocardial cell injury after severe hypoxia.</p><p><b>METHODS</b>Differential expression of the genes in rat myocardium and skeletal muscles after severe hypoxia for 6 hours was determined by DNA chip containing 4096 mice genes.</p><p><b>RESULTS</b>There were high expressions of 125 genes in skeletal muscles and 111 genes in myocardial cells after 6 hours of severe hypoxia. Among them, high expression genes in myocardial cells included those encoding apoptosis activator Mtd, complement C3, vascular cell adhesion molecule-1, integrin beta subunit and lipopolysaccharide binding proteins (LBP).</p><p><b>CONCLUSION</b>Activation of apoptosis of myocardial cells and inflammatory mediators played important roles in myocardial cell injury after 6-hour severe hypoxia.</p>
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Patologia
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Complemento C3
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RNA Mensageiro
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Células Cultivadas
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Músculo Esquelético
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Molécula 1 de Adesão de Célula Vascular
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Proteínas Proto-Oncogênicas c-bcl-2
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Análise de Sequência com Séries de Oligonucleotídeos
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Perfilação da Expressão Gênica
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Miócitos Cardíacos
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
Idioma:
Zh
Revista:
Chinese Journal of Burns
Ano de publicação:
2003
Tipo de documento:
Article