Simultaneous determination of three coumarins in Angelica dahurica var. formosana by QAMS / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To develop a quantitative analysis of multi-components by single marker(QAMS) method for simultaneous determination of three coumarins in Angelica dahurica var. formosana, by using one standard substance.</p><p><b>METHOD</b>With imperatorin as internal reference standard, and 2 relative correction factors (RCF) to imperatorin were calculated within certain ranges. Their contents in 20 batches of samples, collected from different areas, were determined by both external standard method and QAMS. The method was evaluated by comparison of the quantitative results between the two methods.</p><p><b>RESULT</b>No significant differences were found in the quantitative results of three coumarins in 20 batches of A. dahurica var. formosana determined by the two methods (RSD < 5%).</p><p><b>CONCLUSION</b>QAMS is feasible and suitable for quality control of A. dahurica var. formosana.</p>