Protein Interaction Network Construction and Biological Pathway Analysis Related to Atherosclerosis / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 1255-1260, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-357884
ABSTRACT
Atherosclerosis is a complex disease characterized by lipid accumulation in the vascular wall and influenced by multiple genetic and environmental factors. To understand the mechanisms of molecular regulation related to atherosclerosis better, a protein interaction network was constructed in the present study. Genes were collected in nucleotide database and interactions were downloaded from Biomolecular Object Network Database (BOND). The interactional data were imported into the software Cytoscape to construct the interaction network, and then the degree characteristics of the network were analyzed for Hub proteins. Statistical significance pathways and diseases were figured out by inputting Hub proteins to KOBAS2. 0. The complete pathway network related to atherosclerosis was constructed. The results identified a series of key genes related to atherosclerosis, which would be the potential promising drug targets for effective prevention.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Software
/
Bases de Dados Factuais
/
Mapeamento de Interação de Proteínas
/
Aterosclerose
/
Mapas de Interação de Proteínas
/
Genética
/
Métodos
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Chinês
Revista:
Journal of Biomedical Engineering
Ano de publicação:
2015
Tipo de documento:
Artigo
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