Meta-Analysis of Genetic Association Studies
Annals of Laboratory Medicine
; : 283-287, 2015.
Article
em En
| WPRIM
| ID: wpr-36812
Biblioteca responsável:
WPRO
ABSTRACT
The object of this review is to help readers to understand meta-analysis of genetic association study. Genetic association studies are a powerful approach to identify susceptibility genes for common diseases. However, the results of these studies are not consistently reproducible. In order to overcome the limitations of individual studies, larger sample sizes or meta-analysis is required. Meta-analysis is a statistical tool for combining results of different studies on the same topic, thus increasing statistical strength and precision. Meta-analysis of genetic association studies combines the results from independent studies, explores the sources of heterogeneity, and identifies subgroups associated with the factor of interest. Meta-analysis of genetic association studies is an effective tool for garnering a greater understanding of complex diseases and potentially provides new insights into gene-disease associations.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Artrite Reumatoide
/
Receptores Imunológicos
/
Bases de Dados Factuais
/
Polimorfismo de Nucleotídeo Único
/
Estudos de Associação Genética
/
Genótipo
Tipo de estudo:
Prognostic_studies
/
Systematic_reviews
Limite:
Humans
Idioma:
En
Revista:
Annals of Laboratory Medicine
Ano de publicação:
2015
Tipo de documento:
Article