2011 Update of Scientific Statement for the Primary Prevention of Stroke: Dyslipidemia and Inflammation
Journal of the Korean Neurological Association
; : 159-169, 2012.
Article
em Ko
| WPRIM
| ID: wpr-38035
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND: This scientific statement is intended to provide a systematic review of new evidences in dyslipidemia and inflammation for primary stroke prevention. METHODS: Using a structured literature search, we identified major observational studies, clinical trials, meta-analyses, and updated major guidelines published between July 2007 and November 2010. In addition to the brief summary of earlier evidences employed in the first edition of Korean clinical practice guideline for primary prevention of stroke, we summarized the newly identified evidences. RESULTS: For dyslipidemia, observational studies further support a strong association between ischemic stroke and high total and low-density lipoprotein cholesterol and low high-density lipoprotein cholesterol. Two clinical trials and 6 meta-analyses confirm statin efficacy for primary prevention of stroke in high risk patients. Efficacy of other lipid-lowering agents is not established. For inflammation, inflammatory markers might help to identify patients having high risk for stroke or cardiovascular event and to decide whether statin therapy is indicated, but its usefulness for broad population needs to be confirmed. CONCLUSIONS: Writing committee will continue to keep an eye on upcoming evidences to timely update the guideline for primary stroke prevention in dyslipidemia and inflammation.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Prevenção Primária
/
Redação
/
Metanálise como Assunto
/
Colesterol
/
Guias de Prática Clínica como Assunto
/
Inibidores de Hidroximetilglutaril-CoA Redutases
/
Acidente Vascular Cerebral
/
Dislipidemias
/
Olho
/
Inflamação
Tipo de estudo:
Guideline
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Observational_studies
/
Systematic_reviews
Limite:
Humans
Idioma:
Ko
Revista:
Journal of the Korean Neurological Association
Ano de publicação:
2012
Tipo de documento:
Article