Research progress of chemokines in dendritic cell tumor vaccines / 国际外科学杂志

ABSTRACT

Chemokine can regulate the immuue cells migration, play the function by combining chemokine receptor. Dendritic cells(DC) are the most important professional antigen presenting cells, and their main application is prepared into a variety of cancer vaccine. Dendritic cells need to migrate while completing the functions, are related with chemokine and chemokine receptor. Chemokines always playe a regulating, promoting or inhibiting role in the processing of completing the functions and migration. So DC can present antigens, activate the initial T cells, cause immune response and kill the tumor cells and inflammatory molecules.