Characteristics of ventricular electrophysiology in a right ventricular rapid pacing-induced canine heart failure model / 中国病理生理杂志
Chinese Journal of Pathophysiology
; (12): 2116-2121, 2007.
Article
em Zh
| WPRIM
| ID: wpr-407566
Biblioteca responsável:
WPRO
ABSTRACT
AIM:To research the characteristics of ventricular electrophysiology in right ventricular rapid pacing-induced congestive heart failure (CHF) dogs. METHODS:Dogs (n = 16) were randomly divided into 2 groups:the control (n = 7) and the CHF group (n = 9) induced by rapid right ventricular pacing at 240 pulse·min-1 for 4 to 5 weeks. The electrophysiologic parameters were evaluated by the technique of standard electric stimulation and monophasic action potential (MAP) recording. RESULTS:(1) Ventricular effective refractory period (VERP), ventricular MAP duration (MAPD90), ventricular late repolarization duration (VLRD) and intra- ventricular conduction time (IVCT) were prolonged by 26% (P < 0. 01), 43% (P < 0. 01), 318% (P < 0. 05), and 19% (P < 0. 01), respectively in CHF group. (2)The ratio of VERP to MAPD90(VERP/MAPD90) was decreased by 13% (P<0.05) in CHF group. (3) The dispersion of ventricular recovery time (VRT - D) was increased by 185% (P <0. 01) in CHF group. (4) The ventricular fibrillation threshold (VFT) was decreased by 48% (P < 0. 01) in CHF group. CONCLUSION:The abnormal electrophysiological changes in the CHF condition may be contributing factors of lethal ventricular arrhythmias and sudden cardiac deaths in CHF.
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Índice:
WPRIM
Tipo de estudo:
Prognostic_studies
Idioma:
Zh
Revista:
Chinese Journal of Pathophysiology
Ano de publicação:
2007
Tipo de documento:
Article