Observation of curative effect of gastric bypass on type 2 diabetes: a study with eight cases and literature review / 中国医师进修杂志
Chinese Journal of Postgraduates of Medicine
; (36): 6-9, 2011.
Article
em Zh
| WPRIM
| ID: wpr-414494
Biblioteca responsável:
WPRO
ABSTRACT
Objective To investigate the effects of gastric bypass on glycometabolism and improvement of islet β cell function and insulin resistance in patients with type 2 diabetes. Methods Eight patients with type 2 diabetes combined with gastric carcinoma who treated with gastric bypass were studied prospectively. Fasting and postprandial plasma glucose levels, fasting and postprandial insulin C-peptide levels, and body mass index (BMI) were measured right before the surgery and at intervals of 1 week, 2 weeks, 1 month and 3 months after the surgery. Glycosylated hemoglobin (HbA1c) levels were measured before and 3 months after the surgery. The outcome of the diabetes after 3 months of the surgery was also monitored. Results Fasting and postprandial plasma glucose levels decreased (P < 0.05) and fasting and postprandial insulin C-peptide levels increased (P < 0.05) after the surgery. HbA1c levels also decreased (P < 0.05) after 3 months of the surgery. There was no significant change of BMI at all intervals after the surgery(P> 0.05). All of the 8 patients reached the total effective standard and 6 patients reached the clinical remission standard after 3 months of the surgery. Conclusions It suggests that gastric bypass can significantly lower plasma glucose levels in type 2 diabetes, which does not depend on the loss of weight. The control of plasma glucose by gastric bypass may be due to the improvement of islet β cell function and increasing secretion of endogenous insulin.
Texto completo:
1
Índice:
WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Postgraduates of Medicine
Ano de publicação:
2011
Tipo de documento:
Article