Relationship of serum uric acid level with the different states of glucose metabolism and creatinine clearance rate / 中国糖尿病杂志

ABSTRACT

Objective To explore the association of serum uric acid level with the different states of glucose metabolism and glomerular filtration rate (GFR) reflected by creatinine clearance rate and to test the hypothesis that increased GFR is one of the determinants of serum uric acid level. Methods 822 subjects with high risk factors for diabetes in Beijing area underwent a 75g oral glucose tolerance test (OGTT) for screening of diabetes. The subjects were divided into three groupsNGT,IGR and DM after OGTT. SUA and Ccr were compared between three groups. The general linear model was employed to test the relationships of the small FPG intervals with SUA and Ccr. Results The correlations of uric acid level with sex,BMI,TG,HbA1c and Ccr remained significant in a multiple regression analysis. After adjusting sex,BMI and TG,the newly diagnosed DM group had the lowest SUA level(P<0.01) and the highest Ccr(P<0.01). When fasting glucose level was stratified by a grade of 1 to 2mmol/L,we found that the correlation between SUA and FPG levels became significant only when FPG was higher than 7.0 mmol/L(P<0.01) and the correlation between Ccr and FPG levels became significant only when FPG was between 6.0 mmol/L and 10.0 mmol/L (P<0.01). Conclusions This study confirms the previous finding that SUA level decreases in diabetes,and provides a supporting evidence that the increased GFR might contribute to the fall of SUA level