Glycosylated hemoglobin A1c for the diagnosis of diabetes mellitus: a meta-analysis / 中华内科杂志
Chinese Journal of Internal Medicine
; (12): 21-25, 2013.
Article
em Zh
| WPRIM
| ID: wpr-432271
Biblioteca responsável:
WPRO
ABSTRACT
Objective To assess the diagnostic value of glycosylated hemoglobin A1c (HbA1c) ≥6.5% for diabetes in Chinese adults with oral glucose tolerance test(OGTT) as the reference standard.Methods Major databases were searched to get all diagnostic tests with HbA1c ≥ 6.5% for diabetes in Chinese adults.QUADAS items were used to evaluate the quality of the eligible studies.Meta-disc software was used to perform comprehensive quantitative assessment for all included studies and summary ROC (SROC) curve were drawn.Results A total of 11 studies were included.The outcomes of the diagnostic value with HbA1c ≥6.5% were as the following:pooled sensitivity 0.62 (95% CI:0.60-0.64),pooled specificity 0.96 (95% CI:0.95-0.96),diagnostic odds ratio (DOR) 40.25 (95% CI:20.79-77.95) and AUCSROC 0.7702 (sx =0.0636).Conclusions The diagnostic specificity is pretty high for the diagnostic test with HbA1c ≥6.5%,while sensitivity is low.Combination of HbA1c and glucose tests is needed to reduce the missed diagnosis rate.
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Índice:
WPRIM
Tipo de estudo:
Diagnostic_studies
/
Systematic_reviews
Idioma:
Zh
Revista:
Chinese Journal of Internal Medicine
Ano de publicação:
2013
Tipo de documento:
Article