The relationship between human glucocorticoid receptor and steroid-resistant nephrotic syndrome / 中国小儿急救医学

ABSTRACT

Idiopathic nephrotic syndrome is a common pediatric kidney disease,and glucocorticoid is the first choice to deal with it.However,not all children are absolutely sensitive to it,about 10 to 20 percent are steroid-resistant.Researches have shown that human glucocorticoid receptor is associating with steroid-resistant.This article summarized the expression of glucocorticoid receptor and its gene polymorphism in steroid-resistant children.