Changes of mitochondria in human placenta in intrauterine growth restriction / 临床儿科杂志
Journal of Clinical Pediatrics
; (12): 1169-1172, 2013.
Article
em Zh
| WPRIM
| ID: wpr-440081
Biblioteca responsável:
WPRO
ABSTRACT
Objective To explore the mechanism of intrauterine growth restriction (IUGR) via observing the change of mitochondria in IUGR placenta. Methods Placenta samples were collected from 30 singleton pregnancies at the time of elec-tive caesarean section. Fifteen of them were appropriate for gestational age and 15 were IUGR. Mitochondrial morphology was observed by transmission electron microscopy, DNA copies were analyzed by real-time quantitative PCR and membrane potential was assayed by lfow cytometry. Results Signiifcant morphological changes of placental mitochondria were observed under transmission electron microscopy in IUGR, mitochondrial DNA copies in IUGR placenta were signiifcantly increased (P<0.01) and membrane potential decreased dramatically (P<0.01). Conclusions It is suggest that impaired mitochondrial function in IUGR may involve in IUGR pathogenesis.
Texto completo:
1
Índice:
WPRIM
Idioma:
Zh
Revista:
Journal of Clinical Pediatrics
Ano de publicação:
2013
Tipo de documento:
Article