Methylenetetrahydrofolate reductase polymorphism in three nationality in Guizhou / 重庆医学
Chongqing Medicine
; (36): 3413-3415, 2013.
Article
em Zh
| WPRIM
| ID: wpr-441769
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WPRO
ABSTRACT
Objective To identify the distribution feature of methylenetetrahydrofolate reductase (M T HFR) gene polymorphism of Buyi ,Dong ,Miao nationality in Guizhou .Methods The MTHFR(677 and 1 298) genotypes of Buyi ,Miao and Dong healthy indi-viduals were determined by TaqMan-MGB probe genotyping method and constructed haplotypes .Results There were significant difference of MTHFR 677C/T genotype and allele frequencies among 3 groups(P 0 .05) .Buyi nationality had the lowest frequency in double wild homozygous type (677CC/1298AA) ,677TT/1298CC double mutation homozygous and 677TT/1298AC combination in above three minorities was not found .There were linkage disequilibrium between 677C/T and 1298A/C in Buyi and Miao nationality .Conclusion The genotypes frequencies of MTHFR 677T T/1298AC are significant differences among different regions and different ethnic groups .
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Índice:
WPRIM
Idioma:
Zh
Revista:
Chongqing Medicine
Ano de publicação:
2013
Tipo de documento:
Article