Study the effect of Pingchuan formula on Rho/Rock signaling pathway in the mice of asthmatic model / 国际中医中药杂志
International Journal of Traditional Chinese Medicine
; (6): 435-437, 2014.
Article
em Zh
| WPRIM
| ID: wpr-448148
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WPRO
ABSTRACT
Objective To study the effect of Pingchuan Formula(PCF)on Rho/Rock signaling pathway in the mice of asthmatic model, explore the mechanism of PCF on asthma. Methods Forty BALB/C mice were randomly divided into four groupsa control group, a model group,a dexamethasone group and a PCF group. After treated with medicine for 4 weeks, albumen expression of RhoA and RockI in lung tissues were detected by using Western blot, mRNA expressions of RhoA and RockI were detected by using Real-time PCR. Results The albumen and the mRNA expression of RhoA and RockI in the model group were(1.05± 0.20),(1.06±0.08),(6.60±1.09), (6.53±1.84), the control group were(0.76±0.08), (0.84±0.14), (3.82± 1.77), (3.65±1.46),there was a significant difference between two groups(P0.05). Conclusion The expressions of Rho/Rock signaling pathway were controlled significantly by PCF, and the curative effect was similar to dexamethasone.
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WPRIM
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Zh
Revista:
International Journal of Traditional Chinese Medicine
Ano de publicação:
2014
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Article