Relationship between adiponectin -11,377C > G Gene polymorphism and risk of coronary heart disease / 实用医学杂志
The Journal of Practical Medicine
; (24): 2405-2407, 2014.
Article
em Zh
| WPRIM
| ID: wpr-455195
Biblioteca responsável:
WPRO
ABSTRACT
Objective To investigate the relationship between the polymorphism of adiponectin -11 ,377C> G gene and the risk of coronary heart disease(CHD). Methods A total of 126 CHD patients and 130 healthy controls were enrolled and the frequency of each genotypes and allele gene of adiponectin -11 ,377C > G were detected by polymerase chain reaction fragment length polymorphism (PCR-RFLP). Results (1) The adiponectin gene -11,377C > G sites existed gene polymorphism and the three genotypes were GG, CG and CC. (2) There was statistical difference between CHD group and control group; The G allele frequency of CHD group was significantly higher than that in control group (P G between acute coronary syndrome (ACS) group and stable angina group . ( 4 ) The risk of CHD were increased in CHD patients with G allele gene of adiponectin-11,377C > G (P G is associated with the increased risk of CHD. The increased G allele gene frequency may represent the increased risk of CHD.
Texto completo:
1
Índice:
WPRIM
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Idioma:
Zh
Revista:
The Journal of Practical Medicine
Ano de publicação:
2014
Tipo de documento:
Article